Preheat the oven to 375 degrees F (190 degrees C). Grease a 9×5-inch loaf pan with baking spray.
Stir baking mix, white sugar, brown sugar, and pumpkin pie spice together in a bowl. Add beer and stir until smooth. Pour batter into the prepared loaf pan and sprinkle the top with pepitas.
Bake in the preheated oven until a toothpick inserted into the center comes out clean, about 50 minutes. Let cool in the pan for 10 minutes, then remove to a wire rack to cool completely.
I use Bisquick(R) or a homemade baking mix. For the ale, I like Blue Moon(R) Harvest Pumpkin Wheat.
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