Preheat oven to 400 degrees F (200 degrees C). Place drumsticks in a baking dish.
Whisk water, ketchup, vinegar, brown sugar, butter, salt, Worcestershire sauce, mustard, and chili powder together in a bowl; pour mixture over drumsticks. Cover with aluminum foil.
Bake in preheated oven until no longer pink at the bone and the juices run clear, about 1 hour, turning chicken about halfway through. An instant-read thermometer inserted near the bone should read 165 degrees F (74 degrees C).
I usually cook the chicken 10 to 15 minutes longer to thicken the sauce. I like to pair this with mashed potatoes and drizzle a bit of the chicken sauce onto the potatoes. Also amazing with any seasoned rice.
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