Preheat the oven to 350 degrees F (175 degrees C).
Combine flour, oregano, salt, garlic powder, onion powder, Italian seasoning, black pepper, and cayenne pepper in a large bowl. Add ground lamb and thoroughly knead with the flour mixture until thoroughly mixed together, about 3 minutes.
Shape the seasoned ground lamb and place into a loaf pan; set on top of a baking sheet.
Bake in the preheated oven, turning the loaf halfway to ensure even browning, about 1 hour and 20 minutes.
Wrap loaf in aluminum foil and let rest, about 10 minutes. Slice as thinly as possible to make the doner kebab pieces.
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